Peptide Mechanosynthesis by Direct Coupling of N -Protected α-Amino Acids with Amino Esters
نویسندگان
چکیده
منابع مشابه
One-pot synthesis of enantiomerically pure N-protected allylic amines from N-protected α-amino esters
An improved protocol for the synthesis of enantiomerically pure allylic amines is reported. N-Protected α-amino esters derived from natural amino acids were submitted to a one-pot tandem reduction-olefination process. The sequential reduction with DIBAL-H at -78 °C and subsequent in situ addition of organophosphorus reagents yielded the corresponding allylic amines without the need to isolate t...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2016
ISSN: 1434-193X
DOI: 10.1002/ejoc.201600617